VASCULOSIRT -The Ultimate VASCULAR Anti-Aging Supplement

Vascular aging is the most important health care problem in the world today. Healthy aging requires healthy arteries and a healthy heart.

It is fairly well-known today in the news that a “calorie-restricted” diet has been shown to increase the life span of mammals in the laboratory. The mechanism of action for this phenomenon is that it activates the SIRT-1 anti-aging gene in humans. It has also been shown that the compound Resveratrol causes the same phenomenon by activating this same SIRT-1 gene.

Once again Biotics Research Corp leads the nutritional field with their new specialty product VASCULOSIRT.

This product incorporates the latest research findings and the latest in pharmaceutical grade nutrients to provide nutritional support for the arteries and the heart. VASCULOSIRT is a state of the art product, providing comprehensive support for healthy cardiovascular function.

NOTE: This product is fairly expensive for two main reasons.

1. RESVERATROL and

2. VITAMIN K2

Pharmaceutical grades of these two products are expensive as any nutrient in existence. I have seen companies selling Vitamin K2 for $12.95 for 100 capsules. Now folks, as a former registered pharmacist who prefers pharmaceutical grade nutrients, I can assure you there is no way in the world those products are the products the scientists have done research with. And the same goes double for Resveratrol. THESE PRODUCTS ARE EXPENSIVE. So you get what you pay for.

Vascular aging is characterized by progressive arterial stiffness, loss of arterial elasticity and arterial compliance from a myriad of structural and functional changes in the lining of the artery (the endothelium, the adventitia and the vascular media) resulting in:

 Endothelial dysfunction

 Increased extracellular matrix

 Altered vascular smooth muscle (VSMC)

 Altered adventitia

from Mark Houston, M.D., MSc, ABAAM, FACP, FAHA.

Following three years of research, Dr. Mark Houston, Associate Clinical Professor of Medicine at Vanderbilt Medical School and Director of Hypertension Institute and Vascular Biology in Nashville, Tennessee, in conjunction with Biotics Research Corp, have developed a revolutionary nutritional supplement designed to:

• Slow vascular aging
• Promote vascular and heart health
• Slow aging in experimental animals
• Provide healthy support for blood pressure, cholesterol, glucose and insulin levels within normal ranges

KEY COMPONENTS OF VASCULOSIRT:

Resveratrol (Trans-Resveratrol) - a phytoalexin found in certain plants. (Phytoalexins are toxic compounds produced by higher plants in response to attack by pathogens and to other stresses. Sometimes referred to as “plant antibiotics”, but rather non-specific, having a general fungicidal and bacteriocidal action). Resveratrol is easily absorbed and has been shown to:

• Slow aging in experimental animals by 66%
• Simulate caloric restriction and assist in weight control
• Increase Nitric Oxide (NO) production
• Protect DNA from damage
• Increase the activity of SIRT-1, which are a series of anti-aging genes that simulate caloric restriction and longevity in animal studies

R-Alpha Lipoic Acid (R-ALA) - is an active isomer of lipoic acid. R-ALA is believed to be twice as active as traditional Alpha Lipoic Acid, which is a mixture of the R and S forms. R-ALA is found in the mitochondria of cells and improves the function of those mitochondria, increases metabolic rate and decreases oxidative damage. R-ALA enhances glutathione activity and is linked to detoxification of xenobiotics (chemicals which are found in organisms but which are not normally produced or expected to be present in it). R-ALA supports healthy blood pressure, glucose and insulin levels and supports healthy arteries and heart. It also increases the levels of nitric oxide as well.

EGCG (Epigallocatechin Gallate) - a major catechin found in green tea. EGCG is the most potent of all the green tea catechins. It helps prevent atherosclerosis via inhibiting the proliferation of smooth muscle cells in the arteries. Other benefits include:

• Inhibits NFKappa-beta inflammatory mediator
• Thermogenic properties (promotes fat oxidation)
• Chemo-protective
• Supports glucose and insulin levels
• Supports healthy arteries and heart

VITAMIN K (K2 AND K1) - inadequate vitamin K2 levels results in decreased calcium metabolism resulting in the “calcium paradox” – calcification of the arteries and osteoporosis.

Vitamin K2 is found in fermented products, primarily Natto. The Natto K2 supplies menaquinone-7 (MK-7). It is more bioavailable than other forms of Vitamin K. Research shows that vitamin K2 (MK-7) promotes the removal of arterial calcification (plaque) and promotes the deposition of calcium into bone.

ADDITIONAL COMPONENTS

Coenzyme-Q10 (CoQ10) – a fat soluble antioxidant that functions to transfer and manufacture energy (ATP) in the mitochondria. Thus, CoQ10 is crucially important for energy production (ATP) in the heart tissue, and supports healthy blood pressure, arteries and a healthy heart.

Acetyl-L-Carnitine - supports healthy heart function by assisting in the transport of long-chain fatty acids across mitochondrial membranes for energy (ATP) production.

B-Complex vitamins - supports healthy blood pressure, homocysteine, glucose and insulin levels within normal ranges

Vitamin D3 - supports healthy arteries. D3 helps maintain normal blood pressure through various mechanisms in the kidneys (rennin-angiotensin system).

Vitamin C – needed for arterial repair and structural integrity.

Magnesium – supports healthy arteries by specifically preventng atherosclerosis and helps maintain healthy blood pressure.

Olive leaf extract - shows antioxidant properties to help prevent oxidation of LDL cholesterol.

Quercetin - protects against lipid peroxidation and increases the activity of resveratrol by slowing liver metabolism.

Phytolens - a patented antioxidant used by Biotics Research to protect lipids from oxidation and down-regulates pro-inflammatory meadiators.

Ginkobiloba extract - as an antioxidant Ginko protects the endothelial cells of arteries from free-radical damage.

Lutein and Lycopene - natural carotenoids possessing significant antioxidant activity which thus, provides support for healthy arteries.

PRODUCT DESCRIPTION

VASCULOSIRT

** 5 capsules supply:

Vitamin A (from Mixed Carotenoids 3750 IU
Vitamin C (ascorbic acid) 250 mg
Vitamin D3 (as cholecalciferol) 4000IU
Vitamin K2 (as MenaQ7 menaquinone-7 extract of natto) AND
Vitamin K1 ( as phytonadione) 50 mcg
Thiamin (B1) as thiamin mononitrate 5mg
Riboflavin (B2) 5 mg
Niacin (B3) as niacinamide 10 mg
Vitamin B6 50 mg
Vitamin B12 (as resin bound cobolamin) 5 mcg
Biotin 1 mg
Pantothenic Acid (B5) as calcium panothenate 12.5 mg
Magnesium (as magnesium glycinate) 125mg
Coenzyme Q10 100 mg
Trans-Resveratrol (from Polygonum cuspidatum) 50mg
R-Alpha Lipoic Acid 50 mg
Green Tea Extract leaf (50%ECGC) 500 mg
Acetyl-L-Carnitine 500mg
Olive Leaf Extract 50 mg
Quercetin 50 mg
Ginko Biloba Extract (leaf) 5 mg
Phytolens (Lensesculenta extract) 5 mg
Lutein (from marigold flower) 5 mg
Lycopene (from tomato) 1.5 mg

Suggested Use: 5 capsules, twice daily after meals as a dietary supplement or as otherwise directed by a health care professional.

Contains: 300 Capsules
Product #: 2925
NDC: 55146-02925